TR antagonist 1
TR antagonist 1
CAS: 500794-88-7
Molecular Formula: C25H23Br2NO4
TR antagonist 1 - Names and Identifiers
| Name | TR antagonist 1 |
| Synonyms | 500794-88-7 TR antagonist 1 Benzenepropanoic acid, 3,5-dibromo-4-[4-hydroxy-3-(1-methylethyl)-5-[(1E)-2-(4-pyridinyl)ethenyl]phenoxy]- |
| CAS | 500794-88-7 |
TR antagonist 1 - Physico-chemical Properties
| Molecular Formula | C25H23Br2NO4 |
| Molar Mass | 561.26 |
| Storage Condition | 2-8°C，密封，干燥，避光 |
| Use | TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 |
| In vitro study | TR antagonist 1 displays high affinity for both thyroid hormone TRα and TRβ (IC 50 =36 and 22 nM, respectively). TR antagonist 1 acts as a full antagonist in the TRAFR cell assay and the IC 50 32 nM for both TRAFα1 and TRAFβ1. |
| In vivo study | TR antagonist 1 treatment lowers heart rate and shows a possible trend toward an increase of low-density lipoprotein cholesterol (LDL-C) in the cholesterol fed rat model. |
